LOCUS       NC_008226               7881 bp    DNA     circular CON 16-MAY-2014
DEFINITION  Clostridium difficile 630 plasmid pCD630, complete sequence.
ACCESSION   NC_008226
VERSION     NC_008226.1  GI:110666922
DBLINK      Project: 57679
            BioProject: PRJNA57679
KEYWORDS    RefSeq; complete genome.
SOURCE      Peptoclostridium difficile 630 (Clostridium difficile 630)
  ORGANISM  Peptoclostridium difficile 630
            Bacteria; Firmicutes; Clostridia; Clostridiales;
            Peptostreptococcaceae; Peptoclostridium.
REFERENCE   1  (bases 1 to 7881)
  AUTHORS   Monot,M., Boursaux-Eude,C., Thibonnier,M., Vallenet,D., Moszer,I.,
            Medigue,C., Martin-Verstraete,I. and Dupuy,B.
  TITLE     Reannotation of the genome sequence of Clostridium difficile strain
            630
  JOURNAL   J. Med. Microbiol. 60 (PT 8), 1193-1199 (2011)
   PUBMED   21349987
REFERENCE   2  (bases 1 to 7881)
  AUTHORS   Sebaihia,M., Wren,B.W., Mullany,P., Fairweather,N.F., Minton,N.,
            Stabler,R., Thomson,N.R., Roberts,A.P., Cerdeno-Tarraga,A.M.,
            Wang,H., Holden,M.T., Wright,A., Churcher,C., Quail,M.A., Baker,S.,
            Bason,N., Brooks,K., Chillingworth,T., Cronin,A., Davis,P.,
            Dowd,L., Fraser,A., Feltwell,T., Hance,Z., Holroyd,S., Jagels,K.,
            Moule,S., Mungall,K., Price,C., Rabbinowitsch,E., Sharp,S.,
            Simmonds,M., Stevens,K., Unwin,L., Whithead,S., Dupuy,B.,
            Dougan,G., Barrell,B. and Parkhill,J.
  TITLE     The multidrug-resistant human pathogen Clostridium difficile has a
            highly mobile, mosaic genome
  JOURNAL   Nat. Genet. 38 (7), 779-786 (2006)
   PUBMED   16804543
REFERENCE   3  (bases 1 to 7881)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUN-2006) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   4  (bases 1 to 7881)
  AUTHORS   Sebaihia,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-DEC-2005) Sebaihia M., Sulston Laboratories, Wellcome
            Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
            Cambridge, CB10 1SA, UNITED KINGDOM
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AM180356.
            RefSeq Category: (?UNKNOWN?)
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7881
                     /organism="Peptoclostridium difficile 630"
                     /mol_type="genomic DNA"
                     /strain="630"
                     /db_xref="taxon:272563"
                     /plasmid="pCD630"
     gene            complement(<1..99)
                     /locus_tag="CDP01"
                     /db_xref="GeneID:4192061"
     CDS             complement(<1..99)
                     /locus_tag="CDP01"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659577.1"
                     /db_xref="GI:110666923"
                     /db_xref="GeneID:4192061"
                     /translation="MNIQVYESECGNYIFKKSDESFLIDIFDKNGTH"
     gene            complement(257..550)
                     /locus_tag="CDP02"
                     /db_xref="GeneID:4192062"
     CDS             complement(257..550)
                     /locus_tag="CDP02"
                     /inference="similar to sequence:UniProtKB:O80105_9CAUD"
                     /inference="similar to sequence:UniProtKB:Q637A3_BACCZ"
                     /codon_start=1
                     /transl_table=11
                     /product="putative HNH endonuclease"
                     /protein_id="YP_659578.1"
                     /db_xref="GI:110666924"
                     /db_xref="GeneID:4192062"
                     /translation="MAREFSRSFYNSKAWKECRQSIIKKYLGLCAECGKLGEEVHHIK
                     YLTPANIHDVEITLGEENLILLCKDCHSKKHKSKKDITRTGLKFNEKGELISI"
     misc_feature    complement(341..463)
                     /locus_tag="CDP02"
                     /note="HNH nucleases; HNH endonuclease signature which is
                     found in viral, prokaryotic, and eukaryotic proteins. The
                     alignment includes members of the large group of homing
                     endonucleases, yeast intron 1 protein, MutS, as well as
                     bacterial colicins, pyocins, and...; Region: HNHc;
                     cl00083"
                     /db_xref="CDD:260180"
     misc_feature    complement(317..469)
                     /locus_tag="CDP02"
                     /inference="protein motif:HMMPfam:PF01844"
                     /note="protein motif:HNH endonuclease"
     misc_feature    complement(335..352)
                     /locus_tag="CDP02"
                     /inference="protein motif:Prosite:PS00190"
                     /note="protein domain:Cytochrome c family heme-binding
                     site signature."
     gene            complement(550..765)
                     /locus_tag="CDP03"
                     /db_xref="GeneID:4192052"
     CDS             complement(550..765)
                     /locus_tag="CDP03"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659579.1"
                     /db_xref="GI:110666925"
                     /db_xref="GeneID:4192052"
                     /translation="MKKIELDDKEIKLIISALDLKVSRNLGKAYKNFPYAFDEKEEYK
                     RDVATMELLIDKFLSKLNEVECEGVLI"
     gene            complement(1017..2348)
                     /locus_tag="CDP04"
                     /db_xref="GeneID:4192053"
     CDS             complement(1017..2348)
                     /locus_tag="CDP04"
                     /inference="similar to sequence:UniProtKB:Q7Y410_9CAUD"
                     /codon_start=1
                     /transl_table=11
                     /product="putative phage capsid protein"
                     /protein_id="YP_659580.1"
                     /db_xref="GI:110666926"
                     /db_xref="GeneID:4192053"
                     /translation="MTREEYFKKRQEMIDEAQKLLDDEKMEEAEEVTNKIKKLDSSFE
                     AQTKARANLMALEDNNRIQTKARANARALEDNNKIDPMIADIMFNNGSISLSNGETSY
                     SVTSQPVEKNNMYSYTTREGKKIRALNKKDSFRNALNINNFQNLSLGKYIKGMHIGDW
                     KDANIEMEAYKALNTSTGSTLIPSELSAGIIDLARNKMALSNINVIPMETNNLTLAKV
                     KSDPKFSFKKELEVASQSDMEFEGINLKTKTVYGYMKISLELLESAGNIDAIISNAIA
                     ESIASAIDKAGLYGVGEDEPKGVLTYTGINKVNESLISTSKYNGLVKGIGLIKKANGE
                     ATDILYNSNTETDLNLLVDTTGQPLNEPKVVEQIEKTTSNQIKDNQAIVFDRNSILMG
                     LQNSIRIETSREMGFTDGSVYFRVYGFVDFAVMNEKNITLIEYSKTPQDAE"
     misc_feature    complement(1044..1817)
                     /locus_tag="CDP04"
                     /note="Phage capsid family; Region: Phage_capsid;
                     pfam05065"
                     /db_xref="CDD:252984"
     misc_feature    complement(1044..1817)
                     /locus_tag="CDP04"
                     /inference="protein motif:HMMPfam:PF05065"
                     /note="protein motif:Phage capsid family"
     gene            complement(2635..2739)
                     /locus_tag="CDP05"
                     /db_xref="GeneID:4192054"
     CDS             complement(2635..2739)
                     /locus_tag="CDP05"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659581.1"
                     /db_xref="GI:110666927"
                     /db_xref="GeneID:4192054"
                     /translation="MLELYHRKKSISSDFLVNFLWFKGELNWGKKRYK"
     gene            complement(2903..3358)
                     /locus_tag="CDP06"
                     /db_xref="GeneID:4192055"
     CDS             complement(2903..3358)
                     /locus_tag="CDP06"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659582.1"
                     /db_xref="GI:110666928"
                     /db_xref="GeneID:4192055"
                     /translation="MLNSLLNDDNIGTYTYNYINSMFGVGTSYTEEHLEALIVDLQTF
                     LATKKKLTIKRIRLILQSIFVIESKQHRGVTGLPYKYYKNILPSPVTCKKVIRVYTIK
                     KHIDIEDIKKDLGLMDSDLSIEHLVEARINKLLNTIDEADKEVLLEGLI"
     gene            complement(3495..6104)
                     /locus_tag="CDP07"
                     /db_xref="GeneID:4192056"
     CDS             complement(3495..6104)
                     /locus_tag="CDP07"
                     /inference="similar to sequence:UniProtKB:O51577_BORBU"
                     /inference="similar to sequence:UniProtKB:Q6MTE3_MYCMS"
                     /codon_start=1
                     /transl_table=11
                     /product="putative deoxyribonuclease"
                     /protein_id="YP_659583.1"
                     /db_xref="GI:110666929"
                     /db_xref="GeneID:4192056"
                     /translation="MKIDIKQLIDIIKNANIDELYLRDIGVDTTQKGNVPCPIHGGKD
                     KNFQFDLNKRIYTCYSHNCVVGADIIELCRTYEHFEKPIEAILFLANKYNVPLPFTKN
                     KTNTKKINNAPKNIYIKKKDINSFIEEKKQEAFKNNDIELAFEFECMTDKDKRKYYLD
                     NNIKIKSMLEKQNYSSYRADSIIDVDKYISENLKGIRQAIECTTEGENVLMVAPTGSG
                     KTYSIINTLKELDIKALFIFPNSANVQQAIVEYNIAGAYDKIPTKHALKDNNLVAMTW
                     DKTEQLLNEDLSEYIIVIDEIHQTYTDAFRSKAIKSLNNITNKCRGRLDITATPSKLE
                     FEIYNKVIEYKQNIQTEYKVKLYNKINIGKVIEILNNSNNAMLLKDSISTLNYISKKV
                     NKKSGVVISDTKDTSKLYDRIVSYSDMEGYEVLLNTSVIVAGVNINNPNITDIVIIGE
                     KDIGKIKQYVARARGAKSINVHIFNSYKTTNEDSNVYSVEWCINENIKDVESLTNIYN
                     KASKRDLPFKAIGIDISPINIKNIDSNIYYDKKDMCYKTDKLYIKSNAYNNYYQTRAI
                     DSFKVLLEEYFNKIEIIETEKETKKIEEEIKEHEEAIKEFKKSAIEQLEGHKKYLVGY
                     SEIKKSMTSSNLLKYHHDMRIDNNICLKHYMEHDLYSLIINNNCRKTIDLFSGFVLDN
                     SYSIDLAWKLATMGNKGRWSIFDKINKLIYRELKEQYPNFVNDELIGTVVYDYIIKRF
                     GIGTNYTKIHLQELSKDLQILTGAKKMKTTETVGTILNNIFVISSKNYRNVAPLEMCF
                     YKYIYPMGATDNKKVTRINKIERYITLNDIKKELDLKDSDRSLEHLVRSRKDKLLQTI
                     DSDDKEILLNGLA"
     misc_feature    complement(5799..>5996)
                     /locus_tag="CDP07"
                     /note="CHC2 zinc finger; Region: zf-CHC2; cl17510"
                     /db_xref="CDD:248064"
     misc_feature    complement(5034..5516)
                     /locus_tag="CDP07"
                     /note="DEAD-like helicases superfamily; Region: DEXDc;
                     smart00487"
                     /db_xref="CDD:214692"
     misc_feature    complement(5115..5486)
                     /locus_tag="CDP07"
                     /note="DEAD-like helicases superfamily. A diverse family
                     of proteins involved in ATP-dependent RNA or DNA
                     unwinding. This domain contains the ATP-binding region;
                     Region: DEXDc; cd00046"
                     /db_xref="CDD:238005"
     misc_feature    complement(5445..5459)
                     /locus_tag="CDP07"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:238005"
     misc_feature    complement(5211..5222)
                     /locus_tag="CDP07"
                     /note="putative Mg++ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238005"
     misc_feature    complement(5109..5567)
                     /locus_tag="CDP07"
                     /inference="protein motif:HMMPfam:PF04851"
                     /note="protein motif:Type III restriction enzyme, res
                     subunit"
     misc_feature    complement(5445..5468)
                     /locus_tag="CDP07"
                     /inference="protein motif:Prosite:PS00017"
                     /note="protein domain:ATP/GTP-binding site motif A
                     (P-loop)."
     gene            complement(6366..6686)
                     /locus_tag="CDP08"
                     /db_xref="GeneID:4192057"
     CDS             complement(6366..6686)
                     /locus_tag="CDP08"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659584.1"
                     /db_xref="GI:110666930"
                     /db_xref="GeneID:4192057"
                     /translation="MILKDDLLRIGFDTYIENTEDELLENDKKYLNDKKESERIMNRL
                     LEILEEKEHKKMLIDFEEKIYGNGVIEKEYAYRMGVLDGFDLAESINSTKKTMFERGL
                     KYIY"
     misc_feature    complement(6426..6605)
                     /locus_tag="CDP08"
                     /note="Protein of unknown function (DUF3782); Region:
                     DUF3782; pfam12644"
                     /db_xref="CDD:257188"
     gene            6830..6979
                     /locus_tag="CDP09"
                     /db_xref="GeneID:4192058"
     CDS             6830..6979
                     /locus_tag="CDP09"
                     /inference="similar to sequence:UniProtKB:Q34UC3_RHOPA"
                     /inference="similar to sequence:UniProtKB:Q8XP25_CLOPE"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659585.1"
                     /db_xref="GI:110666931"
                     /db_xref="GeneID:4192058"
                     /translation="MLKNRVRFSSSTKPDLFEKLKQLSEQTRIPLTKLIDEALEDLIK
                     KYKLD"
     misc_feature    6839..6970
                     /locus_tag="CDP09"
                     /note="Ribbon-helix-helix domain; Region: RHH_3;
                     pfam12651"
                     /db_xref="CDD:257194"
     gene            7052..7597
                     /locus_tag="CDP10"
                     /db_xref="GeneID:4192059"
     CDS             7052..7597
                     /locus_tag="CDP10"
                     /inference="similar to sequence:UniProtKB:Q3GDE7_9FIRM"
                     /inference="similar to sequence:UniProtKB:Q899Y7_CLOTE"
                     /inference="similar to sequence:UniProtKB:Q89A08_CLOTE"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659586.1"
                     /db_xref="GI:110666932"
                     /db_xref="GeneID:4192059"
                     /translation="MYRYTFDNLPIEEQIKYINNKLLEGNTLTNTCKDIGIGRTTVRN
                     RFKQHGYEFNQAKKLYISIVEVIELESSLKVVTGDTSNDNTLVDATNIDFNNILSKFN
                     DMNNKLNEVYSWYESQSSNKVVGADKLKINDFKGNTVTRSYKVYEDIQKEFAAFCEAN
                     KKYRVQDIISQALKDFMDKYK"
     misc_feature    7127..7192
                     /locus_tag="CDP10"
                     /note="protein motif:helix-turn-helix motif"
     gene            complement(7780..7881)
                     /locus_tag="CDP11"
                     /db_xref="GeneID:4192060"
     CDS             complement(7780..7881)
                     /locus_tag="CDP11"
                     /inference="similar to sequence:UniProtKB:Q8XRD9_RALSO"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_659587.1"
                     /db_xref="GI:110666933"
                     /db_xref="GeneID:4192060"
                     /translation="MGAFGMPSIKTNTICGEKGKFISACDAWLSNLK"
CONTIG      join(AM180356.1:1..7881)
ORIGIN      
        1 atgtgttcca tttttatcaa atatatctat taaaaaactt tcatcagatt ttttaaatat
       61 ataatttcca cattcacttt cataaacttg aatattcatt ttaataactc cttttccttt
      121 ttaatgttcg taaatcattt taaatcaccc cccctccctt ttcatttttt cattcggagg
      181 aaaattgatg tggggacatc ggtatttgaa atcagccccc agggtcgttt ttaagggggg
      241 atatactatt ttttttctaa atcgaaatca attccccttt ttcattaaat tttaaccctg
      301 ttctagtaat gtctttctta ctcttatgtt ttttactatg acagtcttta catagcaata
      361 ttaaattctc ctcacctaaa gttatctcaa catcatgtat attagcagga gttaaatatt
      421 ttatatgatg cacttcttct cctagcttcc cacactcagc acacaagcct agatatttct
      481 taataattga ttgcctacac tccttccaag ctttgctatt ataaaagctt cgactaaact
      541 ctctagccat tatataagca ctccctcaca ctctacctca ttaagcttac ttaaaaactt
      601 atcaatcaaa agctccatag ttgccacatc cctcttatac tcttcttttt catcaaaagc
      661 atatgggaag tttttataag ctttgcctaa gttgcgagaa acttttaaat ctaatgctga
      721 aataatcagt ttaatctctt tatcatccaa ctctattttc ttcataaagc acctcttttt
      781 ctatacgaac attattaaaa actaattaaa tatagttcgt atttcttcat ttgaacgtct
      841 tattttctta gagaaccaga tattcaactt aaatttttcc tacattatat gcactgaatt
      901 tgacccctcg aatgttacta caccaaattt ttagacattc aaataaataa ataaaaaaaa
      961 tactactcta tttattatct ttaaagccct ctaactaaat tagaaggctt ttttatttat
     1021 tcagcatctt gtggagtttt tgaatactct attagtgtta tattcttctc attcatcact
     1081 gcaaagtcaa caaaaccata aactctaaaa tatactgaac catctgtaaa gcccatttct
     1141 cttgatgttt ctattcttat actgttttga agtcccatta atatagaatt tctatcaaat
     1201 actatagctt gattatcttt tatttgattc gaagttgtct tttcaatctg ttcaactacc
     1261 ttaggttcat tcagtggttg tcctgttgta tcaactaata agtttaaatc tgtttcagta
     1321 ttagaattat atagtatatc cgtagcttct ccattggctt tttttataag accaattcct
     1381 tttactaacc cattatactt tgatgtagat attaaacttt catttacttt atttattcct
     1441 gtatatgtca ataccccttt tggttcatct tctccgaccc cataaagtcc agctttatct
     1501 attgcacttg caatagattc tgctatagca tttgatataa ttgcatctat attaccagca
     1561 ctttctaata gctcaagtga gattttcata tagccataga ctgttttagt ttttaggttt
     1621 ataccctcaa attccatatc tgattgactt gcaacttcaa gctctttttt aaaactaaat
     1681 tttgggtcac ttttaacttt agctaaggtt aaattattcg tttccattgg tataacatta
     1741 atgtttgata aagccatttt attcctagct aagtcgatta ttccagctga taactcactt
     1801 ggtataagtg ttgagcctgt actagtattc aaagccttat aagcttccat ttcgatatta
     1861 gcatccttcc agtcacctat gtgcatacct tttatatatt ttcctaagct taaattttga
     1921 aaattattta tatttaaagc atttctaaag ctatcctttt tattcagcgc tctaattttt
     1981 tttccttccc ttgttgtata agaatacatg ttattttttt ctactggttg cgatgtaaca
     2041 ctatatgacg tttctccatt tgataaactt atacttccgt tattaaacat tatatctgct
     2101 atcattgggt caattttatt attatcctct aatgctcttg cattcgctcg agcctttgtt
     2161 tgtattctat tattatcctc taatgccatt aaattagctc gagcctttgt ttgtgcttca
     2221 aatgaactat ctaatttttt tattttatta gtaacttctt cagcttcttc cattttttca
     2281 tcatcaagca atttttgtgc ttcgtctatc atttcttgtc ttttcttaaa atactcttct
     2341 ctagtcattt gtttttcctc ccaatttaaa taagcccaat ttgaattgga ctatttttta
     2401 ttatttctct ttttaagatt caaataaata attttaaata cattcttctt atccactatc
     2461 ttttttaatt cctagttgca aataaagtca cctccaaaac ttttcaataa aaaaagacct
     2521 ctaaataaaa cttagaagtc tttttaattc ttatatgttg caattatata ttatttattt
     2581 agaaagtaat cttcataact ttctacaata taattatagc acacgataat atttttattt
     2641 gtatcttttt tttccccaat ttagttcacc tttaaaccat aaaaaattca ctaaaaaatc
     2701 actagaaata cttttttttc tatgatacaa ttctaacatg ctttctttag aaacgaagta
     2761 taaaaatagt cttttttctg taaaaataat gtttattcta aagcttcatc accatatatc
     2821 ttcaaaataa ttttatgctc caaaatcaag cccttaaaag ttttttattg ttacataact
     2881 cttgtaaata tattttttta tgttaaatta atccttccaa taaaacttcc ttgtctgctt
     2941 catcaatcgt attcaatagt ttatttattc tagcttctac taaatgctct atacttaaat
     3001 cactatccat taatcctaaa tcttttttga tgtcctctat gtctatatgc ttcttaatag
     3061 tatagactct aatcactttt ttacatgtca caggacttgg aagtatattt ttatagtatt
     3121 tatagggaag tcctgtgaca cccctgtgtt gtttactttc aataacaaaa attgattgta
     3181 atattagtct tattctttta atagttagct tctttttagt agctagaaac gtctgcaaat
     3241 caacaattag ggcttctaag tgttcttctg tataacttgt gccaactcca aacattgaat
     3301 taatatagtt ataagtataa gtcccaatat tatcatcatt tagcaaagaa tttaacaaaa
     3361 tatcagcttt tttaatgaaa ttttagcgaa tttattccta tttcaattaa tattagtttg
     3421 atttctaacc ttataaatct ttttaaatta atctctttta agcattcctt ttcaatgtca
     3481 aattgccctt tattttatgc taatccattt aataatatct ctttgtcatc actgtctata
     3541 gtttgcaata acttatcttt acgactacga actaaatgct ctaagcttct atcactatcc
     3601 tttaaatcaa gttctttttt gatgtcattt agagtaatat acctctctat tttgttaatt
     3661 ctagttactt ttttattatc tgtagcaccc atagggtata tatatttata gaaacacatt
     3721 tctaagggtg ctacatttct ataattttta ctgctaatta caaaaatatt gtttagtata
     3781 gtacctacag tttcagtcgt tttcattttt tttgctcctg taagaatctg caaatctttg
     3841 cttaattctt gtaaatgtat ttttgtatag tttgtaccta ttccaaatcg tttaattata
     3901 taatcataaa ctactgttcc tataagttca tcatttacga agttaggata ctgctcctta
     3961 agctctctat agataagttt atttatctta tcaaatatag accatctgcc cttgtttccc
     4021 attgttgcaa gtttccacgc aaggtcaata ctataactat tatctaatac aaaaccactg
     4081 aacaggtcta ttgttttcct gcaattatta ttaattatta gactatataa atcatgttcc
     4141 atgtagtgct ttagacatat gttgttgtct atcctcatgt catgatgata ttttaataag
     4201 ttactgctgg tcattgactt cttaatttca ctatagccaa ctagatactt tttatgtcct
     4261 tctagttgtt ctatagctga tttcttaaat tccttaatag cttcctcatg ctcttttatt
     4321 tcttcctcta tttttttagt ttctttttca gtttctatta tctcaatttt attaaaatat
     4381 tcctctaata gcactttgaa gctatctatt gctcttgttt gatagtagtt attgtaagca
     4441 ttacttttta tatataactt gtccgtttta tagcacatat cctttttatc atagtatata
     4501 ttactatcaa tgttttttat gtttataggg cttatatcaa ttcctattgc tttaaatggt
     4561 aagtctctct tagaagcttt attgtatata tttgttaagc tctcaacgtc ttttatgttc
     4621 tcatttatgc accattcaac cgaatataca ttgctatcct catttgtcgt tttgtaacta
     4681 ttaaaaatat gtacatttat actttttgcc cctctagctc ttgcaacata ctgttttatt
     4741 tttcctatat ctttttcccc tattatgact atatctgtta tgttcggatt atttatattt
     4801 acacctgcaa ctatcacaga agtgttcaaa agcacctcat agccttccat gtcagagtag
     4861 ctgacaattc tatcatatag tttgctagtg tctttagtat ctgaaataac aaccccactc
     4921 tttttattaa ctttctttga tatatagtta agagttgata tactatcttt taaaagcatt
     4981 gcattatttg aattatttag tatctctatt actttcccaa tattgatttt attgtataac
     5041 ttaactttgt attccgtttg tatattttgt ttatattcaa taactttgtt atatatctca
     5101 aattctagtt tagagggtgt tgcagttata tctagtctac ctctgcactt attagttata
     5161 ttatttaagc tctttattgc tttgcttctg aacgcatctg tgtaggtctg atgtatttca
     5221 tcaataacta ttatatattc gcttaaatcc tcatttaaaa gctgttcagt tttatcccat
     5281 gtcatggcta ctaaattgtt gtccttcaaa gcgtgtttag taggtatctt atcatatgca
     5341 ccagctatat tatattcgac tattgcttgt tgcacattcg cagagttggg gaatataaag
     5401 agtgctttta tatccagctc ttttaatgta tttataattg agtatgtttt tccacttcct
     5461 gtaggtgcta ccattaatac attttcaccc tctgtagtac actcaatagc ctgtctaatg
     5521 ccttttaaat tttcacttat gtatttatct acatcaatta ttgaatcggc tctatagctt
     5581 gaatagtttt gtttctctag catagatttt attttaatat tgttatctaa gtaatacttt
     5641 cttttgtcct tatcagtcat acactcaaat tcaaaagcta actcaatatc attgttttta
     5701 aaagcttctt gtttcttttc ttctatgaag ctatttatat cttttttctt tatgtaaatg
     5761 ttttttggag cattatttat ttttttagtg ttggttttat ttttagtaaa tggcaatgga
     5821 acattatact tgttggctaa gaatagtata gcttcaatag gcttttcaaa gtgttcatat
     5881 gtacgacata actcaattat gtctgcacca acaacacaat tatgactata gcatgtatat
     5941 attcttttat ttaaatcgaa ttgaaagttt ttatccttac caccatgaat tgggcaaggg
     6001 acatttcctt tttgagttgt atctactcct atatctctta aatatagttc gtctatatta
     6061 gcatttttta ttatatcaat taattgtttt atatctattt tcatttgtga atttccccct
     6121 tttttttatt aggggctaat caagttttat caagctatgt atttacaatc tgtcgtaaat
     6181 ctcgtataat taacatatga atattttatc tatgttaatt ttatttttca atatgattaa
     6241 cccttaaatg gaaagaatga gtggttgccg tcaaacaaat actcgttctt tttcgttttt
     6301 ttgttattag tattatatca ttaataaaat tataattcat tgtttgaagt tattttttga
     6361 cggttttaat atatatattt caatcctctt tcaaacatag tttttttagt tgagtttata
     6421 gattcagcta ggtcaaaccc atctaaaaca cccattctat acgcatattc tttttcaatt
     6481 acaccgttac catatatttt ttcttcaaaa tcaatcagca tttttttatg ttctttttct
     6541 tccaatattt ctaataatct gttcattatt ctttcagatt cttttttatc atttaaatat
     6601 ttcttgtcat tttctaatag ttcatcctct gtattttcta tgtatgtgtc aaatccaatt
     6661 cttaataaat catcttttaa tatcattttt aacgctcctt ttttataatt tatacaatta
     6721 aaataacata aggtagcata actttcaagc tttaaatggt aattgatgtt acttgcttta
     6781 atgtcatgac atatgtataa tatatttaaa tacgatacag gaggaaaaca tgttaaaaaa
     6841 tagagtacgc ttttcatctt caacaaaacc tgatttattt gaaaaactaa aacaattatc
     6901 tgaacaaaca agaatacctc taactaaatt aatagacgaa gccttagagg atttaattaa
     6961 aaaatacaaa ttagattaat atttttaaag gttcttattt ataactacta gaaagctact
     7021 ttagtagtta ttttattttg gaggtttaaa catgtataga tatacatttg ataatttacc
     7081 tattgaggaa cagataaaat atattaataa caagctctta gagggcaata cattaactaa
     7141 cacatgtaaa gatattggta ttggtcgtac aactgtaaga aatagattta aacaacatgg
     7201 gtatgaattt aatcaagcta agaagctata catatctatt gttgaagtta ttgaattaga
     7261 aagtagttta aaagtagtta cgggcgacac tagcaatgac aatactttag ttgatgcaac
     7321 taacattgat tttaataata ttttatctaa attcaatgat atgaataata aactaaatga
     7381 agtatacagc tggtacgaat cacaaagtag taataaagta gttggggctg ataaactaaa
     7441 aataaatgat tttaagggta atacagtcac tagaagctac aaggtatatg aagatattca
     7501 aaaagagttt gcagccttct gtgaagctaa taagaagtac agggtacaag atattattag
     7561 ccaagctctt aaagatttta tggataaata taagtaacaa cataactact cctaaaattg
     7621 acgtttaggg aatagttaaa catatttcag cattttcaac ctttccctaa acttctattt
     7681 tgaaacttta aaatataaag ttttagtgtt ttttatttta ttaactatta aacacctaac
     7741 aaacttaaaa actttgatta tttctagttt ttattatttt tactttaaat ttgataacca
     7801 agcatcacat gcacttatga attttccctt ttctccacaa attgtatttg tcttaatact
     7861 gggcatccca aacgctccca t
//
